Saeed Solooki; Amir Rahmani Rasa; Narges Ghamari; Mohammad Mehdi Kamravan
Abstract
Background: Ewing's sarcoma is a primitive and malignant bone tumor that is a serious medical challenge in preserving the patient's life and choosing the appropriate treatment. The aim of this study was to consider the metastasis and survival rate after preoperative chemotherapy, surgery and postoperative ...
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Background: Ewing's sarcoma is a primitive and malignant bone tumor that is a serious medical challenge in preserving the patient's life and choosing the appropriate treatment. The aim of this study was to consider the metastasis and survival rate after preoperative chemotherapy, surgery and postoperative chemotherapy as a treatment protocol.Methods: In this study, 42 patients with Ewing's Sarcoma admitted to Chamran and Namazi Hospitals during 2005 to 2016 were enrolled. After considering inclusion and exclusion criteria, 27 patients were finally entered the study. Neo adjuvant chemotherapy and again restaging with MRI and chest CT scan was done. After restaging, treatment was selected. Treatments included amputation; only wide resection; wide resection and allograft; wide resection and prosthesis and only chemotherapy. After surgical treatments, patient had adjuvant chemotherapy.Results: In this study, 42 patients were investigated of whom 29 (%69) were male and 13 (%31) female respectively. The age mean and standard deviation were 21.45± 7.69 and 16.23± 4.9 in the male and female in respect. Femur (%30) and tibia (%23.8), respectively, were the more commonly involved sites. The treatments of 27 cases in the study group were amputation (5 subjects), only wide resection (6 subjects), wide resection and allograft (8 subjects) and wide resection and prosthesis (3 subjects). Patients with pelvis involvement received only chemotherapy (5 subjects). %46.2 of subjects had a 5-year survival period.Conclusion: Early diagnosis of Ewing's sarcoma and appropriate treatment using preoperative chemotherapy followed by, surgery through proper margin removal and then postoperative chemotherapy is highly recommended for this condition. Our study confirmed the above-mentioned points on preoperative chemotherapy followed by surgery and post operative chemotherapy.
Babak Pourabbas Tahvildari; Saeed Solooki; Narges Ghamari; Mohammad Ahmadi Jafari
Abstract
Background: Giant cell tumor (GCT) is a benign bone tumor that may present with invasion and even metastasis in some cases. Despite several techniques for surgical excision of the tumor, its post-operative recurrence is still a critical challenge for orthopaedic surgeons. Therefore, this study ...
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Background: Giant cell tumor (GCT) is a benign bone tumor that may present with invasion and even metastasis in some cases. Despite several techniques for surgical excision of the tumor, its post-operative recurrence is still a critical challenge for orthopaedic surgeons. Therefore, this study aimed to evaluate the result of the surgical treatment of GCTby curettage, burring, alcohol and cementation to reduce the risk of recurrence.Methods: This cross-sectional study was conducted on participants referring to two university hospitals with the diagnosis of GCT in a 12 years period. The subjects underwent surgery using curettage, burring, alcohol irrigation, and cementation. Regular follow-ups were carried out every three months in the first year, and then every six months in the second year and annually from then on.. The recurrence-free survival rate was analyzed by the Kaplan-Meier method.Results: Surgery was performed on 28 patients. The most common tumor site was distal femur, and the most pre-operative and post-operative complaints were pain and limitation of motion, respectively. At the end of the study, local recurrence was observed in only four cases, and lung metastasis was found in one case. The results showed that recurrence-free survival was 91.7% in 21 and 76% in 108 months according to Kaplan-Meier analysis .Conclusion: Although using the above-mentioned protocol seems to reduce the risk of local recurrence in patients with GCTs, complete excision of the tumor is also a crucial factor influencing the rate of local recurrence.
